South Dakota State University has partnered with the South Dakota Department of Health to implement a program of West Nile virus (WNV) research that will support public health decision makers at the state level and mosquito control programs at the local level. Major activities include mosquito surveillance and testing for WNV, monitoring environmental risk factors using data from earth observing satellites, and using this information to predict the risk of WNV to humans across the state. This work is supported in part by a grant from the NASA Applied Sciences Public Health and Air Quality Program (NNX15AF74G).